Whence come warts?

Witch Hunt by SteFou! on Flickr. Used under Creative Commons license. http://www.flickr.com/photos/stephen-oung/5650377059/

(SteFou!/Flickr)

[Today’s post comes at the request of reader Sarah M. Thanks for asking, Sarah!]

Halloween is approaching, and what self-respecting witch or goblin doesn’t have a couple of good-sized warts to show off?

Warts are benign, small growths on the skin caused by an infection with a virus called the human papillomavirus, or HPV. There are four major kinds or warts, divided up by where you find them:

  • Common: Typically found on the hands, sometimes on the face. Also called verruca vulgaris.
  • Plantar: Found on the soles of the feet; also called verruca plantaris. These ones can be quite painful while walking or running.
  • Genital: Found, um, down there; also called verruca acuminata or condyloma acuminata.
  • Sub- or periungual: These crop up under or around the fingernails or toenails.

Most warts are raised and rounded, but they can also be flat. The most common way to get a wart is though a scrape or scratch to the skin that lets the virus in…which may help explain why children seem to be more prone to warts than adults.

Warts can spread from place to place on your body, and can also from someone else to you should you happen to touch either their wart or something that touched it (e.g., a towel). And no, you can’t get warts from touching frogs or toads.

You cannot catch warts from frogs or toads. Toad by joshme17 on Flickr. Used under Creative Commons license. http://www.flickr.com/photos/joshme17/2350952856/in/photolist-4zKfnW-4Zx8ux-57XN6D-5aT9B5-5e5CKW-5Hfxeo-63fMCR-63fVWM-63kbKh-68b98z-6aunzm-6h5Y3F-6oxH7B-6qZ34z-6AsqQ2-6FxNCK-6H9azB-6HdcDo-6TQ3fu-726z9e-726zoP-75aw5u-75awjs-7fBKHP-7iWJXG-7uGwVE-f8UCR4-f8UCYt-8HgiEp-9AbnL1-cNCdiS-8AoHm8-c6W4vC-8zkmfJ-8zhd7R-8zkngq-9GCses-9WZofY-9SHX3Z-8ArJpC-8ArJdS-8ArJDu-8UfcCo-bmBg5Q-9R8gGw-afsqkR-9VCcrU-8AoGcv-8ArKn9-8AoGVk-bUN4z6/

Go ahead. Touch the toad. (joshme17/Flickr)

Where warts come from

As I mentioned above, warts are caused by HPV. There are actually more than 100 types of HPV. Most do nothing more than make you a little warty, though 30 kinds can put you at risk for skin or (in women) cervical cancer.

According to the CDC, HPV is also the most common sexually transmitted infection in the United States. (Hah! In your face, chlamydia!) Forty types of HPV have a predilection for the groin, with just 2 — type 6 and type 11 — causing a whopping 90 percent of all genital warts. Another two — types 16 and 18 — are responsible for most HPV-associated cancers; both are blocked by the HPV vaccine.

Human papilloma virus, the cause of warts.

There’s your culprit: the human papilloma virus. (National Cancer Institute via Wikimedia Commons)

HPVs are small, double-stranded DNA viruses — that is, they carry their genes around inside them in the form of two strands of DNA, like smallpox and herpes (other viruses, such as rotavirus or coronaviruses like MERS, pack their genes in strands of RNA).

Their love of skin cells comes from a protein called L1. Part of HPV’s capsid, or outer coat, L1 helps the virus bind to an as-yet-unidentified receptor on the surface of skin cells called basal epithelial cells, and trigger a series of events that pull the virus into the cell. (Interesting side note: that process may differ from HPV type to HPV type. If you’re interested, read this paper from 2010.)

Once inside a basal epithelial cell, HPV acts like any other virus: it sticks its own genes into the cell’s genome, using the cell’s DNA-copying machinery to make more copies of itself.

Now how do we get from viral DNA to an annoying lump on the sole of your foot? It has to do with what basal epithelial cells (I’ll call them BE cells from here on) do.

Anatomy of the skin from StemBook on Wikimedia Commons. Used under Creative Commons license. http://commons.wikimedia.org/wiki/File:Anatomy_of_the_skin.jpg

Anatomy of the skin. Look at the stratum basale (SB); that’s where the basal epithelial cells live. (StemBook/Wikimedia Commons)

BE cells live in the innermost layer of the epidermis, the outermost layer of your skin. When one of these cells divides, one of the new cells will stay a BE cell and will stay put. The other will start to climb its way up to the surface of your skin and, in the process, turn into a keratinocyte. If that initial BE cell happens to be infected with HPV, when it divides the new keratinocyte will carry the virus with it.

From HPV’s point of view, keratinocytes are a dead end. That’s because they’re what’s termed a terminally differentiated cell — a cell that’s not going to divide or turn into anything else — and they turn their DNA-copying machinery off. And if an HPV-infected keratinocyte isn’t copying its DNA, it won’t make any more viruses.

But the virus has a trick up its sleeve. It jimmies the lock on the genes that control DNA copying and cell division in the keratinocyte, forcing those genes to turn back on and the keratinocyte to start copying its DNA and dividing. Infected keratinocytes start to accumulate and voilà: you’ve got yourself a wart. (This 2001 review paper on HPV binding has the details.)

Warts are hardy little buggers — there are over-the-counter treatments that can help get rid of common or plantar, but they take weeks or months. (My older son had a plantar wart that hung on for what must of hung have been three or four months). For genital warts or warts on the face, you’ll want to go to the doctor.

Maybe that’s why witches are so warty. It’s tough to get a doctor to help treat your warts when you keep turning them into newts.

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One response to “Whence come warts?

  1. It is approved by the United States’ Food and Drug Administration (FDA).
    These viruses belong to the human papillomavirus family (HPV) and more than one
    hundred different ones have been identified. Now the problem with this to doing the home freeze kit is most effective for smaller warts and
    it’s really just not as powerful as your physicians freezing devices;
    which utilizes compacted liquid nitrogen (it gets allot colder).
    We found other merchants selling it for almost exactly half that.

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